Understanding the genetic complexity of puberty timing across the allele frequency spectrum

This research was supported by the UK Medical Research Council (MRC; Unit program MC_UU_00006/2) and has been conducted using the UK Biobank Resource under application 9905. Other study-specific acknowledgements can be found in the Supplementary Information.

Cohorts should be contacted individually for access to their raw data, which are not publicly available as they contain information that could compromise the privacy of their research participants. UK Biobank data are available on the application (https://www.ukbiobank.ac.uk/enable-your-research/register). Summary statistics from the European-only and ancestry-combined meta-analyses, excluding 23andMe, are available via https://doi.org/10.17863/CAM.107943. Access to the full summary statistics, including 23andMe results, can be obtained from 23andMe after completion of a Data Transfer Agreement (https://research.23andme.com/dataset-access/). We used the NCBI RefSeq gene map for GRCh37, which is available via http://hgdownload.soe.ucsc.edu/goldenPath/hg19/database/. GTEx eQTL V7 data were used and are available via https://gtexportal.org. Genes linked to rare monogenic disorders were annotated from the OMIM database (via OMIM; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University; accessed November 2023, https://omim.org/).