Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19

This study is co-financed by the European Regional Development Fund of the European Union and Greek national funds through the Operational Program “Competitiveness, Entrepreneurship and Innovation (EPAnEK), NSRF 2014-2020 (Project code MIS: OΠΣ 5047228 ).” The Young Finns Study has been financially supported by the Academy of Finland: grants 322098 , 286284 , 134309 (Eye), 126925 , 121584 , 124282 , 255381 , 256474 , 283115 , 319060 , 320297 , 314389 , 338395 , 330809 , and 104821 , 129378 (Salve), 117797 (Gendi), and 141071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001 ); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjö Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (grant 755320 for TAXINOMISIS and grant 848146 for To Aition); European Research Council (grant 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation, Finnish Society of Clinical Chemistry and the Cancer Foundation Finland. NFBC1966 31-year follow up that included cytokine measurements received financial support from University of Oulu Grant no. 65354 , Oulu University Hospital Grant no. 2/97 , 8/97 , Ministry of Health and Social Affairs Grant no. 23/251/97 , 160/97 , 190/97 , National Institute for Health and Welfare, Helsinki Grant no. 54121 , Regional Institute of Occupational Health, Oulu, Finland Grant no. 50621 , 54231 . The data generation, curation and manpower were also supported by the following EU H2020 grants: DynaHEALTH (grant no 633595 ), LifeCycle ( 733206 ), LongITools ( 873749 ), EarlyCause ( 848158 ), EDCMET ( 825762 ) and the Medical Research Council, UK: grant number MRC/BBSRC MR/S03658X/1 ( JPI HDHL H2020 ).

All data used in this work are presented in the online data supplement and are available in the original publications. The code used for this paper is available in Supplementary Text. Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request. The paper has been written in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology using Mendelian Randomization (STROBE-MR) guidelines (Supplementary Text).