Longitudinal metabolomics of increasing body-mass index and waist-hip ratio reveals two dynamic patterns of obesity pandemic

3121 General medicine, internal medicine and other clinical medicine

This work was supported by Academy of Finland, Novo Nordisk foundation, Oulu Health and Wellfare Center, Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, ERDF European Regional Development Fund, EU Horizon 2020, EU Research Council and following foundations: Sigrid Juselius, Finnish Cardiovascular Research, Juho Vainio, Paavo Nurmi, Finnish Cultural, Tampere Tuberculosis, Emil Aaltonen, Yrjö Jahnsson, Signe and Arne Gyllenberg, and Finnish Diabetes Research. The Young Finns Study has been financially supported by the Academy of Finland grants 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjö Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreements No 848146 for To Aition and grant agreement 755320 for TAXINOMISIS; European Research Council (grant 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation and Finnish Society of Clinical Chemistry. Open Access funding provided by University of Oulu including Oulu University Hospital.

The datasets used in the current study are available from the cohorts through application process for researchers who meet the criteria for access to confidential data: https://thl.fi/en/web/thl-biobank/for-researchers/apply (FINRISK 1997 cohorts), https://www.oulu.fi/nfbc/ (NFBC1966), and http://youngfinnsstudy.utu.fi (YFS). Regarding the YFS data the Ethics committee has concluded that under applicable law, the data from this study cannot be stored in public repositories or otherwise made publicly available. The data controller may permit access on case-by-case basis for scientific research, not however to individual participant level data, but aggregated statistical data, which cannot be traced back to the individual participants’ data.