Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc

1182 Biochemistry, cell and molecular biology

The Core Facility for Biophysics, Structural Biology, and Screening (BiSS) at the University of Bergen has received infrastructure funding from the Research Council of Norway through NORCRYST (grant number 245828) and NOR–OPENSCREEN (grant number 245922). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

The crystallographic data presented in this manuscript are available at the Protein Data Bank with the following accession numbers: 8QF3 (nanobody H11; https://doi.org/10.2210/pdb8QF3/pdb), 8QF4 (Arc-NL bound to nanobody H11; https://doi.org/10.2210/pdb8QF4/pdb), 8QF5 (Arc-NL bound to nanobody E5; https://doi.org/10.2210/pdb8QF5/pdb).