Bayesian risk prediction model for colorectal cancer mortality through integration of clinicopathologic and genomic data

3122 Cancers

This work was supported by U.S. National Institutes of Health (NIH) grants (P01 CA87969; UM1 CA186107; P01 CA55075; UM1 CA167552; U01 CA167552; R01 CA137178 to A.T.C.; K24 DK098311 to A.T.C.; R35 CA197735 to S.O.; R01 CA151993 to S.O.; R01 CA248857 to S.O.; K07 CA188126 to X.Z.; R21 CA252962 to X.Z.; R37 CA225655 to J.K.L.; and R35 GM142879 to K.-H.Y.); by Cancer Research UK Grand Challenge Award (UK C10674/A27140 to K.N., M.G., and S.O.); by Nodal Award (2016–02) from the Dana-Farber Harvard Cancer Center (to S.O.); by the Stand Up to Cancer Colorectal Cancer Dream Team Translational Research Grant (SU2C-AACR-DT22–17 to C.S.F. and M.G.), administered by the American Association for Cancer Research, a scientific partner of SU2C; and by grants from the Project P Fund, the Crush Colon Cancer Fund, The Friends of the Dana-Farber Cancer Institute, Bennett Family Fund, and the Entertainment Industry Foundation through National Colorectal Cancer Research Alliance and SU2C. J.B. was supported by a grant from the Australia Awards-Endeavour Scholarships and Fellowships Program. K.H. was supported by fellowship grants from the Uehara Memorial Foundation and the Mitsukoshi Health and Welfare Foundation. K.F. was supported by a fellowship grant from the Uehara Memorial Foundation. K.A. was supported by a grant from Overseas Research Fellowship (JP2018–60083) from the Japan Society for the Promotion of Science. T.U. was supported by grants from Prevent Cancer Foundation and Harvey V. Fineberg Fellowship in Cancer Prevention. S.A.V. was supported by the Finnish Cultural Foundation and Orion Research Foundation. M.G. is supported by an ASCO Conquer Cancer Foundation Career Development Award and a High Pointe Investigatorship in Gastrointestinal Oncology. A.T.C. is a Stuart and Suzanne Steele MGH Research Scholar. J.A.M. research is supported by the Douglas Gray Woodruff Chair Fund, the Guo Shu Shi Fund, Anonymous Family Fund for Innovations in Colorectal Cancer, P fund and the George Stone Family Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Due to participant confidentiality and privacy concerns, data are available upon reasonable written request. Further information including the procedures to obtain and access data from the Nurses’ Health Studies and Health Professionals Follow-up Study is described at https://www.nurseshealthstudy.org/researchers (contact email: nhsaccess@channing.harvard.edu) and https://sites.sph.harvard.edu/hpfs/for-collaborators/.