Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse

3111 Biomedicine, 3123 Gynaecology and paediatrics

NPG was supported by MATER Marie Sklodowska-Curie which received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 813707. K.L., T.L., M.L., and R.M. are supported by the Estonian Research Council grant PRG687. This study was supported by the European Union from the Horizon 2020 grant INTERVENE. This study was funded by European Union through the European Regional Development Fund Project No. 2014-2020.4.01.15-0012 GENTRANSMED. Computations were performed in the High Performance Computing Center, University of Tartu. T.L.P., R.A., and H.R. are supported by the Academy of Finland grants no 315921 and 321763 and Sigrid Juselius foundation. We want to acknowledge the participants and investigators of the Icelandic, FinnGen, UKBB, and EstBB studies. The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS

The full meta-analysis summary statistics generated in this study have been deposited in the GWASCatalog (https://www.ebi.ac.uk/gwas/) under accession code GCST90102470. The PRS summary statistics generated in this study have been deposited in the PGS Catalog (https://www.pgscatalog.org/) database under accession code PGS002288. The individual level data from Estonian Biobank are available under restricted access for containing sensitive information from healthcare registers, access can be obtained through the Estonian biobank upon submission of a research plan and signing a data transfer agreement. All data access to the Estonian Biobank must follow the informed consent regulations of the Estonian Committee on Bioethics and Human Research, which are clearly described in the Data Access section at https://genomics.ut.ee/en/ content/estonian-biobank. A preliminary request for raw genetic and phenotype data must first be submitted via the email address releases@ut.ee. Icelandic and UKBB summary statistics can be accessed from http://www.decode.com/summarydata and FinnGen summary statistics can be downloaded after filling this form (https://elomake. helsinki.fi/lomakkeet/102575/lomake.html). We queried mouse mutant phenotypes utilizing Mouse Genome Database (MGI6.18, latest update from 05/04/2022) (http:// www.informatics.jax.org/).